Bildgebungssonde mit Selektivität für lösliches Tau-aggregiertes  Protein

sikopharma

sikopharma

A fluorescent molecular imaging probe with selectivity for soluble tau-aggregated   protein

Soluble forms of aggregated, misfolded tau protein, commonly referred to as oligomers, are considered to be the most toxic species of the various assemblies that are the pathological components of neurodegenerative diseases. Therefore, there is a critical biomedical  need for imaging probes that can identify and quantify them. We  designed and synthesized a novel fluorescent probepTP-TFE, for which binding and selectivity  profiles towards aggregated tau and Aβ proteins were examined  . Our results have shown that   pTP-TFE   is selective for early forms of soluble tau aggregates, with a high affinity of the dissociation constant ( Okay   d  ) = 66 nM and a ten-fold selectivity towards mature tau fibrils.

Darüber hinaus fanden wir, dass  pTP-TFE  für Tau gegenüber Aβ-Aggregaten selektiv ist und eine gute Zellpermeabilität aufwies . Diese Selektivität von  pTP-TFE  gegenüber frühen Formen von aggregiertem Tau-Protein  ex vivo  wurde auch durch Studien an menschlichem Hirngewebe unterstützt, das Tau- und Aβ-Pathologie enthält. Nach unserem besten Wissen ist dies das erste fluoreszierende Molekül, über das berichtet wird, dass dieses Selektivitätsprofil aufweist, was darauf hindeutet, dass  pTP-TFE  ein einzigartiger Sondenkandidat für die bildgebende Detektion von frühen Stadien der Alzheimer-Krankheit und anderer Tauopathien ist.

Die orale Verabreichung von Mind  Protein  kombiniert mit Probiotika induziert Immuntoleranz Durch die Tryptophan Pathway

Übermäßige Entzündungen führen zu sekundären Immunschäden nach Schädel-Hirn-Trauma (SHT). Die Darmschleimhaut ist aufgrund der Darm-Hirn-Achsen-Regulierung eine Schlüsselkomponente der Immuntoleranz, aber die heilende Wirkung ist nicht optimum. Eine Darmfunktionsstörung beeinträchtigt die Etablierung einer Immuntoleranz bei Patienten mit SHT. Daher haben wir Gehirn oral verabreichtProtein (BP) kombiniert mit Probiotika, um eine Immuntoleranz zu induzieren, und erforschte den Mechanismus, durch den die Homöostase der Mikrobiota zur Verstärkung der heilenden Wirkung von BPs beiträgt. Hierin zeigten wir, dass Patienten mit TBI und chirurgischen Hirnverletzungsmodellen (SBI) von Ratten eine offensichtliche Dysbiose aufwiesen. Insbesondere die Darmbarriere, proinflammatorische Zytokine und die Aktivierung von Mikroglia zeigten, dass übermäßige Entzündungsschäden in der kombinierten Gruppe (orale Verabreichung von BP in Kombination mit Probiotika) besser kontrolliert wurden als in der BP-Gruppe (orale Verabreichung von BP). Grundsätzlich zeigte eine Tandem-Mass-Tag (TMT)-basierte quantitative Proteomik-Analyse, dass BP und Probiotika bevorzugt Strive-bezogene Signalwege beeinflussen.

Eine Reihe von Experimenten bestätigte außerdem, dass die Expression des Indoleamin-2,3-Dioxygenase (IDO)/Kyurenin (Kyn)/Aryl-Kohlenwasserstoff-Rezeptor (AhR) in der BP-Gruppe hoch warfare, während Tryptophan-Hydroxylase 1(TpH1)/5-Hydroxytryptamin (5-HT ) nur in der kombinierten Gruppe geändert. Diese Studie legt nahe, dass Probiotika die Wirksamkeit der oralen BP-induzierten Immuntoleranz über den Strive-Weg verbessern können .

 

sikopharma
sikopharma
DNAAF5 Antibody (HRP)
20-abx308300
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
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DNAAF5 Antibody (FITC)
20-abx308301
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  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
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DNAAF5 Antibody (Biotin)
20-abx308302
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
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DNAAF5 Polyclonal Antibody
A58814 100 µg
EUR 570.55
Description: reagents widely cited
DNAAF5 Antibody, HRP conjugated
1-CSB-PA771471LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against DNAAF5. Recognizes DNAAF5 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA
DNAAF5 Antibody, FITC conjugated
1-CSB-PA771471LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against DNAAF5. Recognizes DNAAF5 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
DNAAF5 Antibody, Biotin conjugated
1-CSB-PA771471LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against DNAAF5. Recognizes DNAAF5 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA
DNAAF5 Polyclonal Antibody, Biotin Conjugated
A58815 100 µg
EUR 570.55
Description: Ask the seller for details
DNAAF5 Polyclonal Antibody, FITC Conjugated
A58816 100 µg
EUR 570.55
Description: The best epigenetics products
DNAAF5 Polyclonal Antibody, HRP Conjugated
A58817 100 µg
EUR 570.55
Description: kits suitable for this type of research
Human Dynein Assembly Factor 5, Axonemal / HEATR2 (DNAAF5) ELISA Kit
abx387761-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
H2B Antibody Antibody
AF4659 200ul
EUR 376
Description: H2B Antibody Antibody detects endogenous levels of H2B.
CD11b Antibody Antibody
ABD2911 100 ug
EUR 438
anti- Antibody^Polyclonal antibody control antibody
LSMab09882 100 ug
EUR 438
Ly1 Antibody Reactive (LYAR) Antibody
20-abx123734
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  • EUR 592.00
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Anti-Glycolipid Antibody (AGA) Antibody
abx036399-100ug 100 ug
EUR 391
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Ly1 Antibody Reactive (LYAR) Antibody
abx033330-400ul 400 ul
EUR 523
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Ly1 Antibody Reactive (LYAR) Antibody
abx033330-80l 80 µl
EUR 286
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Ly1 Antibody Reactive (LYAR) Antibody
20-abx008109
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
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Anti-Glycolipid Antibody (AGA) Antibody
20-abx004855
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  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
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Ly1 Antibody Reactive (LYAR) Antibody
20-abx014333
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
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Ly1 Antibody Reactive (LYAR) Antibody
20-abx324434
  • EUR 314.00
  • EUR 244.00
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Anti-Glycoprotein Antibody (GP) Antibody
20-abx319900
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
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Anti-Glycoprotein Antibody (GP) Antibody
20-abx319901
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  • EUR 599.00
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Anti-Glycoprotein Antibody (GP) Antibody
20-abx319905
  • EUR 411.00
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  • EUR 599.00
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Anti-Glycoprotein Antibody (GP) Antibody
20-abx319913
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Ly1 Antibody Reactive (LYAR) Antibody
20-abx311665
  • EUR 411.00
  • EUR 1845.00
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  • EUR 182.00
  • EUR 300.00
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Ly1 Antibody Reactive (LYAR) Antibody
abx234901-100ug 100 ug
EUR 551
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Anti-Glycolipid Antibody (AGA) Antibody
abx230204-100ug 100 ug
EUR 481
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Anti-Anti-SEPT2 Antibody antibody
STJ28365 100 µl
EUR 277
Anti-Anti-SEPT7 Antibody antibody
STJ28963 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
Anti-Anti-SEPT6 antibody antibody
STJ11100949 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.
Anti-Anti-SEPT2 Antibody antibody
STJ25475 100 µl
EUR 277
Anti-Anti-SEPT5 Antibody antibody
STJ25477 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Anti-Anti-SEPT8 Antibody antibody
STJ25479 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Anti-Anti-SEPT9 Antibody antibody
STJ111369 100 µl
EUR 277
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.
Anti-Anti-SEPT11 Antibody antibody
STJ111530 100 µl
EUR 277
Anti-Anti-SEPT4 Antibody antibody
STJ112276 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.
Anti-Anti-MARCH9 Antibody antibody
STJ112609 100 µl
EUR 277
Anti-Anti-SEPT11 Antibody antibody
STJ113941 100 µl
EUR 277
Anti-Anti-SEPT11 Antibody antibody
STJ114081 100 µl
EUR 277
Anti-Anti-SEPT5 Antibody antibody
STJ114819 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Anti-Anti-MARCH8 Antibody antibody
STJ114828 100 µl
EUR 277
Anti-Anti-MARCH6 Antibody antibody
STJ118549 100 µl
EUR 277
Anti-Anti-MARCH6 Antibody antibody
STJ118550 100 µl
EUR 277
Anti-Anti-MARCH7 Antibody antibody
STJ118752 100 µl
EUR 277
Anti-Anti-SEPT3 Antibody antibody
STJ118990 100 µl
EUR 277
Anti-Anti-SEPT1 antibody antibody
STJ119580 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]
Anti-Anti-SEPT7 Antibody antibody
STJ116214 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
Anti-Anti-SEPT8 Antibody antibody
STJ117206 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Anti-Anti-SEPT12 Antibody antibody
STJ117759 100 µl
EUR 277
Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.
Monoclonal NGF/proNGF Neutralizing Antibody Antibody
AMM06679G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human NGF/proNGF Neutralizing. The antibodies are raised in Mouse. This antibody is applicable in E
Ly1 Antibody Reactive Homolog (LYAR) Antibody
20-abx103034
  • EUR 453.00
  • EUR 133.00
  • EUR 1302.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Ly1 Antibody Reactive Homolog (LYAR) Antibody
20-abx103035
  • EUR 467.00
  • EUR 133.00
  • EUR 1344.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Ly1 Antibody Reactive Homolog (LYAR) Antibody
20-abx103036
  • EUR 481.00
  • EUR 133.00
  • EUR 1414.00
  • EUR 662.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
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  • Shipped within 5-7 working days.
Hepatitis C Virus Antibody (HCV) Antibody
abx023924-1mg 1 mg
EUR 1205
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Anti-Glycoprotein Antibody (GP) Antibody (HRP)
20-abx319902
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
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Anti-Glycoprotein Antibody (GP) Antibody (FITC)
20-abx319903
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
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  • Shipped within 5-10 working days.
Anti-Glycoprotein Antibody (GP) Antibody (Biotin)
20-abx319904
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Anti-Glycoprotein Antibody (GP) Antibody (HRP)
20-abx319906
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
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  • 50 ug
  • Shipped within 5-10 working days.
Anti-Glycoprotein Antibody (GP) Antibody (FITC)
20-abx319907
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Anti-Glycoprotein Antibody (GP) Antibody (Biotin)
20-abx319908
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Anti-Glycoprotein Antibody (GP) Antibody (HRP)
20-abx319914
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Anti-Glycoprotein Antibody (GP) Antibody (FITC)
20-abx319915
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Anti-Glycoprotein Antibody (GP) Antibody (Biotin)
20-abx319916
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Anti-Glycoprotein Antibody (GP) Antibody (HRP)
20-abx319929
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Anti-Glycoprotein Antibody (GP) Antibody (FITC)
20-abx319930
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Anti-Glycoprotein Antibody (GP) Antibody (Biotin)
20-abx319931
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Ly1 Antibody Reactive (LYAR) Antibody (HRP)
20-abx311666
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Ly1 Antibody Reactive (LYAR) Antibody (FITC)
20-abx311667
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Ly1 Antibody Reactive (LYAR) Antibody (Biotin)
20-abx311668
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Anti Deoxyribonucleic Acid Antibody (DNA) Antibody
abx411057-50ug 50 ug
EUR 592
  • Shipped within 1 week.
Anti-Glycoprotein 210 Antibody (gp210) Antibody
abx233571-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.
Cytokeratin 7 antibody-Cytoskeleton Marker Antibody
48169-100ul 100ul
EUR 333
Cytokeratin 7 antibody-Cytoskeleton Marker Antibody
48169-50ul 50ul
EUR 239
Anti CD22 Antibody: CD22 Monoclonal Antibody
065-A-01mg 0,1 mg
EUR 267.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD22 monoclonal antibody
Anti CD22 Antibody: CD22 Monoclonal Antibody
065-A-1000ug 1000 ug
EUR 1282.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD22 monoclonal antibody
Antibody Pair to ApoA-V antibody
10R-1876 100 ul
EUR 651
Description: Mouse monoclonal Antibody Pair to ApoA-V antibody
Goat anti- human Antibody^Polyclonal antibody
LSMab09896 100 ug
EUR 438
Anti-Noelin Antibody BIOTIN Antibody BIOTIN
STJ501938 100 µg
EUR 586
Anti-Noelin Antibody FITC Antibody FITC
STJ501939 100 µg
EUR 586
Anti-Noelin Antibody BIOTIN Antibody BIOTIN
STJ501940 100 µg
EUR 586
Anti-Noelin Antibody FITC Antibody FITC
STJ501941 100 µg
EUR 586
Antibody for Human alpha Tubulin Antibody
SPC-692D 0.1mg
EUR 354
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is unconjugated.
Antibody for Human alpha Tubulin Antibody
SPC-692D-A390 0.1mg
EUR 401
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 390.
Antibody for Human alpha Tubulin Antibody
SPC-692D-A488 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 488.
Antibody for Human alpha Tubulin Antibody
SPC-692D-A565 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 565.
Antibody for Human alpha Tubulin Antibody
SPC-692D-A594 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 594.
Antibody for Human alpha Tubulin Antibody
SPC-692D-A633 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 633.
Antibody for Human alpha Tubulin Antibody
SPC-692D-A655 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 655.
Antibody for Human alpha Tubulin Antibody
SPC-692D-A680 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 680.
Antibody for Human alpha Tubulin Antibody
SPC-692D-A700 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 700.
Antibody for Human alpha Tubulin Antibody
SPC-692D-ALP 0.1mg
EUR 394
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Alkaline Phosphatase.
Antibody for Human alpha Tubulin Antibody
SPC-692D-APC 0.1mg
EUR 399
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to APC .
Antibody for Human alpha Tubulin Antibody
SPC-692D-APCCY7 0.1mg
EUR 471
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to APC/Cy7.
Antibody for Human alpha Tubulin Antibody
SPC-692D-BI 0.1mg
EUR 396
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Biotin.
Antibody for Human alpha Tubulin Antibody
SPC-692D-DY350 0.1mg
EUR 414
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Dylight 350.
Antibody for Human alpha Tubulin Antibody
SPC-692D-DY405 0.1mg
EUR 403
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Dylight 405.
Antibody for Human alpha Tubulin Antibody
SPC-692D-DY488 0.1mg
EUR 393
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Dylight 488.
Antibody for Human alpha Tubulin Antibody
SPC-692D-DY594 0.1mg
EUR 395
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Dylight 594.
Antibody for Human alpha Tubulin Antibody
SPC-692D-DY633 0.1mg
EUR 390
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Dylight 633.
Antibody for Human alpha Tubulin Antibody
SPC-692D-FITC 0.1mg
EUR 392
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to FITC.
Antibody for Human alpha Tubulin Antibody
SPC-692D-HRP 0.1mg
EUR 388
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to HRP.
Antibody for Human alpha Tubulin Antibody
SPC-692D-P594 0.1mg
EUR 407
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to PE/ATTO 594.
Antibody for Human alpha Tubulin Antibody
SPC-692D-PCP 0.1mg
EUR 399
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to PerCP.
Antibody for Human alpha Tubulin Antibody
SPC-692D-RPE 0.1mg
EUR 397
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to RPE .
Antibody for Human alpha Tubulin Antibody
SPC-692D-STR 0.1mg
EUR 398
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Streptavidin.
Antibody for Human alpha Tubulin Antibody
SPC-692S 0.012mg
EUR 65
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is unconjugated.
Anti-IgG1 Negative Control Antibody antibody
STJ16100881 1 mL
EUR 478
AXL Antibody
AF8412 200ul
EUR 376
Description: AXL Antibody detects endogenous levels of total AXL.
MUC1 Antibody
AF8524 200ul
EUR 376
Description: MUC1 Antibody detects endogenous levels of total MUC1.
A1Up Antibody
AF9002 200ul
EUR 304
Description: A1Up Antibody detects endogenous levels of total A1Up.
Acrosin Antibody
AF9003 200ul
EUR 304
Description: Acrosin Antibody detects endogenous levels of total Acrosin.
AIFL Antibody
AF9005 200ul
EUR 304
Description: AIFL Antibody detects endogenous levels of total AIFL.
AMPKgamma2 Antibody
AF9006 200ul
EUR 304
Description: AMPKgamma2 Antibody detects endogenous levels of total AMPKgamma2.
ANKRD20 Antibody
AF9008 200ul
EUR 304
Description: ANKRD20 Antibody detects endogenous levels of total ANKRD20.
APOBEC3A Antibody
AF9009 200ul
EUR 304
Description: APOBEC3A Antibody detects endogenous levels of total APOBEC3A.
ApoOL Antibody
AF9010 200ul
EUR 304
Description: ApoOL Antibody detects endogenous levels of total ApoOL.
ARHGAP1 Antibody
AF9011 200ul
EUR 304
Description: ARHGAP1 Antibody detects endogenous levels of total ARHGAP1.
ARHGAP22 Antibody
AF9012 200ul
EUR 304
Description: ARHGAP22 Antibody detects endogenous levels of total ARHGAP22.
ARHGEF19 Antibody
AF9013 200ul
EUR 304
Description: ARHGEF19 Antibody detects endogenous levels of total ARHGEF19.
ARMCX1 Antibody
AF9014 200ul
EUR 304
Description: ARMCX1 Antibody detects endogenous levels of total ARMCX1.
Arrdc1 Antibody
AF9016 200ul
EUR 304
Description: Arrdc1 Antibody detects endogenous levels of total Arrdc1.
ARRDC2 Antibody
AF9017 200ul
EUR 304
Description: ARRDC2 Antibody detects endogenous levels of total ARRDC2.
Arrdc4 Antibody
AF9018 200ul
EUR 304
Description: Arrdc4 Antibody detects endogenous levels of total Arrdc4.
ASF1B Antibody
AF9022 200ul
EUR 304
Description: ASF1B Antibody detects endogenous levels of total ASF1B.
BAM32 Antibody
AF9023 200ul
EUR 304
Description: BAM32 Antibody detects endogenous levels of total BAM32.
BEGAIN Antibody
AF9024 200ul
EUR 304
Description: BEGAIN Antibody detects endogenous levels of total BEGAIN.
BRD3 Antibody
AF9025 200ul
EUR 304
Description: BRD3 Antibody detects endogenous levels of total BRD3.
BTBD6 Antibody
AF9026 200ul
EUR 304
Description: BTBD6 Antibody detects endogenous levels of total BTBD6.
Cables2 Antibody
AF9029 200ul
EUR 304
Description: Cables2 Antibody detects endogenous levels of total Cables2.
CaMKIbeta Antibody
AF9031 200ul
EUR 304
Description: CaMKIbeta Antibody detects endogenous levels of total CaMKIbeta.
CAS Antibody
AF9032 200ul
EUR 304
Description: CAS Antibody detects endogenous levels of total CAS.
CD158f2 Antibody
AF9037 200ul
EUR 304
Description: CD158f2 Antibody detects endogenous levels of total CD158f2.
CD32 Antibody
AF9038 200ul
EUR 304
Description: CD32 Antibody detects endogenous levels of total CD32.
Cdc16 Antibody
AF9039 200ul
EUR 304
Description: Cdc16 Antibody detects endogenous levels of total Cdc16.
Centrobin Antibody
AF9040 200ul
EUR 304
Description: Centrobin Antibody detects endogenous levels of total Centrobin.
CEP152 Antibody
AF9041 200ul
EUR 304
Description: CEP152 Antibody detects endogenous levels of total CEP152.
CMTM4 Antibody
AF9042 200ul
EUR 304
Description: CMTM4 Antibody detects endogenous levels of total CMTM4.
CNOT2 Antibody
AF9043 200ul
EUR 304
Description: CNOT2 Antibody detects endogenous levels of total CNOT2.
COL19A1 Antibody
AF9044 200ul
EUR 304
Description: COL19A1 Antibody detects endogenous levels of total COL19A1.
COL4A6 Antibody
AF9045 200ul
EUR 304
Description: COL4A6 Antibody detects endogenous levels of total COL4A6.
COL5A3 Antibody
AF9046 200ul
EUR 304
Description: COL5A3 Antibody detects endogenous levels of total COL5A3.
CRSP130 Antibody
AF9049 200ul
EUR 304
Description: CRSP130 Antibody detects endogenous levels of total CRSP130.
CYB561D1 Antibody
AF9050 200ul
EUR 304
Description: CYB561D1 Antibody detects endogenous levels of total CYB561D1.
CYP4F2 Antibody
AF9051 200ul
EUR 304
Description: CYP4F2 Antibody detects endogenous levels of total CYP4F2.
Eg5 Antibody
AF9058 200ul
EUR 304
Description: Eg5 Antibody detects endogenous levels of total Eg5.
Eps8L3 Antibody
AF9061 200ul
EUR 304
Description: Eps8L3 Antibody detects endogenous levels of total Eps8L3.
eRF3a Antibody
AF9062 200ul
EUR 304
Description: eRF3a Antibody detects endogenous levels of total eRF3a.
ETL Antibody
AF9063 200ul
EUR 304
Description: ETL Antibody detects endogenous levels of total ETL.
FAM80B Antibody
AF9064 200ul
EUR 304
Description: FAM80B Antibody detects endogenous levels of total FAM80B.
FBP3 Antibody
AF9065 200ul
EUR 304
Description: FBP3 Antibody detects endogenous levels of total FBP3.
FoxR1 Antibody
AF9067 200ul
EUR 304
Description: FoxR1 Antibody detects endogenous levels of total FoxR1.
GAAP Antibody
AF9068 200ul
EUR 304
Description: GAAP Antibody detects endogenous levels of total GAAP.
GALR3 Antibody
AF9069 200ul
EUR 304
Description: GALR3 Antibody detects endogenous levels of total GALR3.
GAS3 Antibody
AF9070 200ul
EUR 304
Description: GAS3 Antibody detects endogenous levels of total GAS3.
GBP4 Antibody
AF9071 200ul
EUR 304
Description: GBP4 Antibody detects endogenous levels of total GBP4.
GPR124 Antibody
AF9073 200ul
EUR 304
Description: GPR124 Antibody detects endogenous levels of total GPR124.
GPR139 Antibody
AF9074 200ul
EUR 304
Description: GPR139 Antibody detects endogenous levels of total GPR139.
GPR41 Antibody
AF9075 200ul
EUR 304
Description: GPR41 Antibody detects endogenous levels of total GPR41.

C-reaktives  Protein-  Albumin-Verhältnis (CAR) als Prädiktor für Anastomoseninsuffizienz in der kolorektalen Chirurgie

Hintergrund:  Anastomoseninsuffizienz (AL) ist eine der schwerwiegendsten Komplikationen in der kolorektalen Chirurgie. Derzeit sind keine prädiktiven Biomarker für AL verfügbar. Das Ziel dieser Studie warfare es, die Rolle des C-reaktiven Proteins (CRP) zu Albumin- Verhältnis (CAR) als Prädiktor für AL bei Patienten zu untersuchen, die sich einer elektiven Operation wegen Darmkrebs unterziehen.

Materials und Methoden: Es wurden  Daten von 1183 konsekutiven Patienten erhoben, die in den an der Studie beteiligten chirurgischen Einheiten wegen histologisch nachgewiesenem Dickdarmkrebs operativ behandelt wurden. Die Daten umfassten Geschlecht, Alter, BMI, ASA-Rating, Charlson-Komorbiditätsindex, Lokalisation, Histologie und Stadium der Erkrankung sowie Bluttests einschließlich Albumin und CRP am 4. postoperativen Tag. Unterschiede in CAR zwischen Patienten, die AL entwickelten und denen, die keine AL entwickelten, wurden analysiert, und die Fähigkeit von CAR, AL vorherzusagen, wurde mit ROC-Analyse untersucht.

Ergebnisse:  CAR warfare bei Patienten mit AL signifikant höher als bei Patienten ohne, am 4. postoperativen Tag. In der ROC-Analyse zeigte CAR eine gute Fähigkeit zum Nachweis von AL (AUC 0,825, 95% CI: 0,786-0,859), größer als die von CRP und Albumin allein. CAR zeigte auch eine hohe Fähigkeit, postoperative Todesfälle zu erkennen (AUC 0,750, 95% CI 0,956–0,987). Diese Ergebnisse wurden in einer multivariaten Analyse unter Einbeziehung der relevantesten Risikofaktoren für AL bestätigt.

Schlussfolgerung:  Unsere Studie zeigte, dass CAR, ein kostengünstiger und weit verbreiteter Laborbiomarker, AL und Tod bei Patienten, die sich einer elektiven Operation wegen Darmkrebs unterzogen haben, angemessen vorhersagt.

Die Rolle von TRIM-  Proteinen  in PRR-Signalwegen und immunvermittelten Erkrankungen

Mustererkennungsrezeptoren (PRRs) sind eine Artwork Erkennungsmolekül , das hauptsächlich auf Zellen des angeborenen Immunsystems exprimiert wird. PRRs erkennen eine oder mehrere Arten von Pathogen-assoziierten molekularen Mustern (PAMPs), die die Produktion von Interleukin (IL), Tumornekrosefaktor (TNF), Interferon (IFN) und anderen verwandten Zytokinen induzieren, um immunvermittelte Krankheiten zu verschlimmern. PPR-Signalwege spielen sowohl im angeborenen als auch im adaptiven Immunsystem eine wichtige Rolle und sind leicht zu aktivieren oder zu regulieren.

Tripartite Motiv (TRIM) Proteine ​​sind eine Gruppe von hochkonservierten Proteinen in der Struktur. Die meisten TRIM-Proteine ​​enthalten eine RING-Domäne, von der angenommen wird, dass sie eine Rolle bei der Ubiquitinierung spielt. TRIM-Proteine ​​sind an der viralen Immunität, Entzündungsreaktion, Autophagie und Tumorwachstum beteiligt. In diesem Evaluation konzentrieren wir uns auf die Regulation von TRIM-Proteinen auf PRR-Signalwegen und ihre Rolle bei immunvermittelten Erkrankungen.

Rekonstituierte kryokonservierte Blutplättchen synthetisieren  Proteine  während der Kurzzeitlagerung und verpacken eine definierte Untermenge in Mikrovesikel

Hintergrund: Die  Kryokonservierung von Thrombozyten (PLTs) könnte ihre Haltbarkeit auf Jahre verlängern, verglichen mit Tagen für flüssig gelagerte Thrombozyten. Aufgrund ihrer stärkeren hämostatischen Wirkung könnten rekonstituierte kryokonservierte Thrombozyten (Kryo-PLTs) Blutungsnotfälle unterstützen. Da die Proteinsynthese mit PLT-Funktionen wie Gerinnselbildung und Immunantworten in Verbindung gebracht wurde, wurde die Translationskapazität rekonstituierter Kryo-PLTs nach Auftauen und kurzzeitiger Lagerung untersucht.

Methoden/Materialien:  Blutplättchen wurden bei –80°C mit 5-6% DMSO eingefroren. Nach dem Auftauen wurden sie in Plasma rekonstituiert und dann aliquotiert (12 ml) in Minibeutel und über 24 h Lagerung bei RT bewertet . Eine Serie diente als Kontrolle; die zweite und dritte Serie wurden entweder mit 300 μM Puromycin (Pm) oder 227 nM Biotin-markiertem Pm gespikt. Die Proben wurden auf In-vitro-Qualität und PLT-Mikrovesikelzählung mittels Durchflusszytometrie getestet. Die Proteinsynthese in Kryo-PLTs wurde mit einer modifizierten Methode bewertet, die auf Puromycin-assoziierter Proteomik der naszierenden Kette basiert.

Ergebnisse:  In-vitro-Parameter von rekonstituierten und anschließend gelagerten Thrombozyten stimmten mit zuvor veröffentlichten Ergebnissen überein. Massenspektrometrische Analysen ergaben, dass 22 Proteine ​​in PLTs synthetisiert wurden und 13 davon in Thrombozyten-Mikrovesikeln (PMVs) beobachtet wurden.

Schlussfolgerung:  Kryo-PLTs können nach Rekonstitution und Lagerung Proteine ​​synthetisieren . Die Entdeckung einer Untergruppe dieser Proteine ​​im PMV legt eine möglicherweise selektive Rolle bei der Vesikelverkapselung nahe. Diese Beobachtung liefert neue Einblicke in die Fähigkeit zur Proteinsynthese in Kryo-PLTs und die potenzielle Regulierung der Proteinverpackung in PMV.

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